Holders Real Madrid will have to overcome a sizeable obstacle when the Champions League resumes in February after Monday's draw pitted the 12-times winners against Paris St Germain.
Bidding for a hat-trick of titles in Europe's elite club competition, Real paid a heavy price for not winning their group as they were drawn with the big-spending Parisians who were tipped as many people's favourites ahead of the draw in Nyon.
Five-time champions Barcelona will face English champions Chelsea, one of five Premier league clubs in the draw.
Tottenham Hotspur, who topped their group ahead of Real Madrid thanks to a 3-1 victory at Wembley, will face Series A champions and last seasons' runners-up Juventus.
Manchester City, who clocked up a record 14th successive Premier League victory on Sunday, are now listed as favourites after being handed a last-16 clash with Swiss club Basel.
Five-times winners Bayern Munich, who finished below PSG in the group, will be happy with a two-legged clash with Turkish outsiders Besiktas.
Europa League champions Manchester United take on Sevilla while, Liverpool will meet Porto while AS Roma's reward for winning their group ahead of Chelsea is a tricky tie against Ukraine's Shakhtar Donetsk.
First Leg: 13-21 February
Juventus (Italy) vs Tottenham (England)
Basel (Switzerland) vs Manchester City (England)
Porto (Portugal) vs Liverpool (England)
Sevilla (Spain) vs Manchester United (England)
Real Madrid (Spain) vs Paris Saint-Germain (France)
Shakhtar Donetsk (Ukraine) vs Roma (Italy)
Chelsea (England) vs Barcelona (Spain)
Bayern Munich (Germany) vs Besiktas (Turkey)
Second Leg: 6-14 March
Tottenham (England) vs Juventus (Italy)
Manchester City (England) vs Basel (Switzerland)
Liverpool (England) vs Porto (Portugal)
Manchester United (England) vs Sevilla (Spain)
Paris Saint-Germain (France) vs Real Madrid (Spain)
Roma (Italy) vs Shakhtar Donetsk (Ukraine)
Barcelona (Spain) vs Chelsea (England)
Besiktas (Turkey) vs Bayern Munich (Germany)
(This article has been edited for length.)
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