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Stephen Hawking, who sought to explain some of the most complicated questions of life while himself working under the shadow of a likely premature death, has died at 76.
The UK's Press Association reported his death, citing a spokesman for the family.
Hawking's formidable mind probed the very limits of human understanding both in the vastness of space and in the bizarre sub-molecular world of quantum theory, which he said could predict what happens at the beginning and end of time.
His work ranged from the origins of the universe itself, through the tantalising prospect of time travel to the mysteries of space's all-consuming black holes.
But the power of his intellect contrasted cruelly with the weakness of his body, ravaged by the wasting motor neurone disease he contracted at the age of 21.
The disease spurred him to work harder but also contributed to the collapse of his two marriages, he wrote in a 2013 memoir "My Brief History."
In the book he related how he was first diagnosed: "I felt it was very unfair – why should this happen to me," he wrote.
"At the time, I thought my life was over and that I would never realise the potential I felt I had. But now, 50 years later, I can be quietly satisfied with my life."
He said he wrote the book to convey his own excitement over recent discoveries about the universe.
“My original aim was to write a book that would sell on airport bookstalls," he told reporters at the time. “In order to make sure it was understandable I tried the book out on my nurses. I think they understood most of it."
(This story has been published in an arrangement with Reuters.)
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