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Gaining weight from your mid-20s into middle age is associated with an increased risk of premature death, warn researchers.
According to the study published in the BMJ journal, weight loss at older ages (from middle to late adulthood) was also linked to higher risk.
For the study, researchers based in China set out to investigate the association between weight changes across adulthood and mortality.
This is a nationally representative annual survey that includes interviews, physical examinations and blood samples, to gauge the health of the US citizens.
Their analysis included 36,051 people aged 40 years or over with measured body weight and height at the start of the survey (baseline) and recalled weight at young adulthood (25 years old) and middle adulthood (average age 47 years).
Deaths from any cause and specifically from heart diseases were recorded for an average of 12 years, during which time there were 10,500 deaths.
After taking account of potentially influential factors, the researchers found that people who remained obese throughout adult life had the highest risk of mortality, while people who remained overweight throughout adult life had a very modest or no association with mortality.
Weight loss over this period was not significantly related to mortality.
But as people got older, the association between weight gain and mortality weakened, whereas the association with weight loss from middle to late adulthood became stronger and significant.
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