Are you wondering why your COVID test results taken during daytime is different from that at night? The virus might act differently depending on the time of day and the body's circadian rhythms, claimed a study.

Their results, published in the Journal of Biological Rhythms, indicate that viral load is lower after 8 p.m. If people choose to get tested at that time, there could be a higher chance of a false-negative result.

False negatives can be harmful to the community and for the patient, who might not seek additional care due to their negative test result.

The data support the hypothesis that COVID-19 acts differently in the body based on our natural circadian rhythm, which has also been implied by studies of other viral and bacterial infections.

"Taking a COVID-19 test at the optimal time of day improves test sensitivity and will help us to be accurate in diagnosing people who may be infected but asymptomatic," said Carl Johnson, Professor of Biological Sciences, at Vanderbilt.

A difference in COVID-19 viral shedding throughout the day is important information that may inform how we test for and treat the virus.

The peak shedding in the afternoon, when patients are more likely to interact with others or seek medical care, could also play a role in increasing the spread of the virus in hospitals and the wider community.

However, further research is needed to confirm the diurnal – meaning active during the day – nature of SARS-CoV-2, the virus that causes COVID-19, Johnson said.

The researchers believe temporal considerations may be leveraged to maximise the effectiveness of intervention strategies and even vaccine strategies.

(This story was published from a syndicated feed. Only the headline and picture has been edited by FIT.)